The crossover experiment for clinical trials

Biometrics. 1980 Mar;36(1):69-79.


The two-period crossover or changeover design for clinical trials is compared with other simple designs in terms of statistical precision and cost. The sensitivity of the crossover to bias due to carryover effects is examined. The feasibility of using the crossover data to test for the existence of carryover effects is investigated and found to be uneconomical. A numerical example is presented.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Clinical Trials as Topic / economics
  • Clinical Trials as Topic / methods*
  • Humans
  • Probability
  • Random Allocation
  • Research Design*