Chromatin condensation in isolated rat hepatocyte nuclei induced by ribonuclease treatment

Experientia. 1980 Feb 15;36(2):181-3. doi: 10.1007/BF01953719.

Abstract

Ribonuclease treatment of isolated rat hepatocyte nuclei induced a 75% solubilization in hnRNA, a reduction of the quantity of perichromatin fibrils, and a marked condensation of chromatin.

MeSH terms

  • Animals
  • Cell Nucleus / ultrastructure*
  • Chromatin / drug effects
  • Chromatin / ultrastructure*
  • Liver / ultrastructure*
  • Liver Regeneration
  • Microscopy, Electron
  • RNA, Heterogeneous Nuclear / analysis*
  • Rats
  • Ribonucleases / pharmacology*

Substances

  • Chromatin
  • RNA, Heterogeneous Nuclear
  • Ribonucleases