HLA, atopy, and cyclophosphamide in steroid-responsive childhood nephrotic syndrome

Kidney Int. 1980 Jan;17(1):113-7. doi: 10.1038/ki.1980.13.


In a study designed to confirm our preliminary report of associations between HLA-B12, atopy, and relapse following cyclophosphamide treatment in steroid-responsive nephrotic syndrome (SRNS), we again found a higher incidence of HLA-B12 in SRNS children (44%) than we did in controls (24%). The association of HLA-B12 with short time-to-relapse after cyclophosphamide treatment of SRNS was also confirmed, but that with atopy in SRNS children was not, though we observed a similarly high incidence of atopy in them as before.

MeSH terms

  • Asthma / immunology
  • Child
  • Cyclophosphamide / therapeutic use*
  • Eczema / immunology
  • HLA Antigens*
  • Humans
  • Hypersensitivity, Immediate / immunology*
  • Immunoglobulin E / metabolism
  • Nephrotic Syndrome / drug therapy*
  • Nephrotic Syndrome / immunology
  • Recurrence
  • Rhinitis, Allergic, Seasonal / immunology
  • Skin Tests
  • Time Factors


  • HLA Antigens
  • Immunoglobulin E
  • Cyclophosphamide