Partial denervation in inactive muscle effects innervated and denervated fibres equally

Nature. 1980 May 22;285(5762):233-5. doi: 10.1038/285233a0.


Possible causal factors of denervation-induced changes in muscle include inactivity, products of nerve degeneration and lack of a nerve-borne trophic agent. We now show that if the innervated fibres in a partially denervated rat muscle are rendered inactive, they undergo a reaction as intense as that of the denervated fibres. This provides further support for the view that the effects of denervation on the extrajunctional muscle membrane result from a combination of muscle inactivity and of nerve breakdown products acting diffusely throughout the muscle.

MeSH terms

  • Action Potentials / drug effects
  • Animals
  • Motor Endplate / drug effects
  • Muscle Denervation*
  • Muscles / drug effects
  • Muscles / physiology*
  • Nerve Degeneration
  • Rats
  • Tetrodotoxin / pharmacology


  • Tetrodotoxin