Inhibition of kidney tubule induction by charged polymers

Cell Differ. 1978 Dec;7(6):345-53. doi: 10.1016/0045-6039(78)90035-0.

Abstract

Charged polymers, known to alter cell surface characteristics, reversibly inhibit the intercellular communication required in kidney tubule induction. This effect seems to be a function of their charge density. It is suggested that this effect is due to the formation of a molecular barrier between the interacting cell surfaces.

MeSH terms

  • Animals
  • Cell Differentiation / drug effects*
  • Chondroitin Sulfates / pharmacology
  • Culture Techniques
  • Dextrans / pharmacology
  • Embryonic Induction / drug effects*
  • Heparin / pharmacology
  • Kidney Tubules / drug effects*
  • Kidney Tubules / embryology
  • Kidney Tubules / metabolism
  • Mice
  • Polylysine / pharmacology
  • Polymers / pharmacology*

Substances

  • Dextrans
  • Polymers
  • Polylysine
  • Heparin
  • Chondroitin Sulfates