Differential susceptibility of 3 sublines of C57BL/6 mice to the induction of colorectal tumors by 1,2-dimethylhydrazine

Cancer Lett. 1980 Apr;9(2):111-5. doi: 10.1016/0304-3835(80)90114-7.

Abstract

Eight-week-old mice of 3 sublines of strain C57BL/6 were given s.c. injections of 1,2-dimethylhydrazine (DMH), once weekly for 10 weeks. The highest incidence (85%) of colorectal tumors occurred in C57BL/6N mice. Colorectal tumors occurred in 43% of C57BL/6J mice, while only 3 (10%) C57BL/6Ha mice developed these tumors. Possible factors responsible for the differential susceptibility of 3 sublines of C57BL/6 mice to the induction of colorectal tumors by DMH are discussed.

Publication types

  • Comparative Study

MeSH terms

  • Adenocarcinoma / chemically induced*
  • Adenoma / chemically induced*
  • Animals
  • Colonic Neoplasms / chemically induced*
  • Dimethylhydrazines / administration & dosage
  • Dimethylhydrazines / toxicity*
  • Disease Susceptibility
  • Injections, Subcutaneous
  • Methylhydrazines / toxicity*
  • Mice
  • Mice, Inbred C57BL
  • Neoplasms, Experimental / chemically induced
  • Rectal Neoplasms / chemically induced*

Substances

  • Dimethylhydrazines
  • Methylhydrazines