Haemodynamic effects of nicergoline in man at rest and during exercise

Clin Exp Pharmacol Physiol. 1980 Mar-Apr;7(2):105-12. doi: 10.1111/j.1440-1681.1980.tb00051.x.

Abstract

1. The intravenous administration of nicergoline (5 mg) was followed by a rapid and sustained lowering of blood pressure; less rapid effects were bradycardia and an elevation of cardiac output. These delayed effects are consistent with an indirect action on the alpha-adrenoreceptors of the central nervous system. 2. Following the oral administration of nicergoline (30 mg), a partial reduction of exercise-induced lactacidaemia was demonstrated, which is consistent with the haemodynamic changes shown at rest.

MeSH terms

  • Administration, Oral
  • Adult
  • Ergolines / pharmacology*
  • Hemodynamics / drug effects*
  • Humans
  • Injections, Intravenous
  • Male
  • Nicergoline / administration & dosage
  • Nicergoline / pharmacology*
  • Physical Exertion
  • Rest
  • Time Factors

Substances

  • Ergolines
  • Nicergoline