Esophageal carcinoma in rats induced by N-amyl-N-methylnitrosamine

Gan. 1980 Feb;71(1):94-9.

Abstract

N-Amyl-N-methylnitrosamine (AMN) induced esophageal carcinoma in Donryu strain rats when given in drinking water. The incidence of carcinomas was high when AMN was given as 0.0015% solution for 90 days or 0.003% solution for 60 days. There was no difference in the incidence in males and females. Sequential studies showed that 4-week administration was necessary to induce esophageal papillomas, and 8-week administration to induce esophageal carcinomas. Whole-body autoradiography after intravenous injection of N-amyl-N-methyl[14C]-nitrosamine (14C-AMN) indicated that AMN accumulated preferentially in the esophagus.

MeSH terms

  • Age Factors
  • Animals
  • Autoradiography
  • Carcinogens / metabolism
  • Carcinogens / toxicity*
  • Carcinoma / chemically induced*
  • Esophageal Neoplasms / chemically induced*
  • Esophageal Neoplasms / pathology
  • Esophagus / pathology
  • Female
  • Male
  • Neoplasms, Experimental / chemically induced
  • Nitrosamines / metabolism
  • Nitrosamines / toxicity*
  • Papilloma / chemically induced*
  • Rats
  • Time Factors
  • Tissue Distribution

Substances

  • Carcinogens
  • Nitrosamines
  • N-amyl-N-methylnitrosamine