Abstract
New antitumor antibiotics, macbecins I and II, were isolated from the culture broth of Nocardia sp. No. C-14919. Macbecins I and II belong to the ansamycin group and have a benzoquinone and hydroquinone nucleus, respectively. Both showed antitumor activity against murine leukemia P 388 in vivo.
MeSH terms
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Animals
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Antibiotics, Antineoplastic / biosynthesis
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Antibiotics, Antineoplastic / isolation & purification*
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Antibiotics, Antineoplastic / pharmacology
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Benzoquinones
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Chemical Phenomena
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Chemistry, Physical
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Fermentation
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Lactams, Macrocyclic
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Leukemia P388 / drug therapy
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Mice
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Nocardia / metabolism
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Oxidation-Reduction
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Quinones / biosynthesis
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Quinones / isolation & purification
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Quinones / pharmacology
Substances
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Antibiotics, Antineoplastic
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Benzoquinones
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Lactams, Macrocyclic
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Quinones
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macbecin I
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macbecin II