Macbecins I and II, new antitumor antibiotics. II. Isolation and characterization

J Antibiot (Tokyo). 1980 Feb;33(2):205-12. doi: 10.7164/antibiotics.33.205.

Abstract

New antitumor antibiotics, macbecins I and II, were isolated from the culture broth of Nocardia sp. No. C-14919. Macbecins I and II belong to the ansamycin group and have a benzoquinone and hydroquinone nucleus, respectively. Both showed antitumor activity against murine leukemia P 388 in vivo.

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic / biosynthesis
  • Antibiotics, Antineoplastic / isolation & purification*
  • Antibiotics, Antineoplastic / pharmacology
  • Benzoquinones
  • Chemical Phenomena
  • Chemistry, Physical
  • Fermentation
  • Lactams, Macrocyclic
  • Leukemia P388 / drug therapy
  • Mice
  • Nocardia / metabolism
  • Oxidation-Reduction
  • Quinones / biosynthesis
  • Quinones / isolation & purification
  • Quinones / pharmacology

Substances

  • Antibiotics, Antineoplastic
  • Benzoquinones
  • Lactams, Macrocyclic
  • Quinones
  • macbecin I
  • macbecin II