Self-catalyzed inactivation of hepatic cytochrome P-450 by ethynyl substrates

J Biol Chem. 1980 Jun 25;255(12):5578-85.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetylene / pharmacology
  • Alkynes / pharmacology*
  • Animals
  • Cytochrome P-450 Enzyme System / metabolism*
  • Male
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / metabolism*
  • Phenobarbital / pharmacology
  • Pigments, Biological / analysis
  • Rats
  • Spectrophotometry
  • Structure-Activity Relationship

Substances

  • Alkynes
  • Pigments, Biological
  • Cytochrome P-450 Enzyme System
  • Acetylene
  • Phenobarbital