Hepatotoxicity associated with use of D-penicillamine in rheumatoid arthritis

Ann Rheum Dis. 1980 Apr;39(2):152-4. doi: 10.1136/ard.39.2.152.


Two patients with rheumatoid arthritis developed evidence of hepatotoxicity while receiving D-penicillamine. Both recovered after withdrawal of the drug. These cases and a review of the literature suggested that hepatotoxicity, though rare, should be added to the list of adverse reactions to D-penicillamine.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Arthritis, Rheumatoid / drug therapy*
  • Chemical and Drug Induced Liver Injury*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Penicillamine / adverse effects*
  • Penicillamine / therapeutic use


  • Penicillamine