A possible association between influenza vaccination and small-vessel vasculitis

Arch Intern Med. 1980 Jun;140(6):847-8.


We describe two patients who experienced small-vessel vasculitic syndromes after influenza immunization. Their illnesses were characterized by fever, arthralgias, and myalgias; uveitis and optic neuritis occurred in one patient, while the other had palpable purpura, which histologically was proved to be a cutaneous necrotizing venulitis. No viral or bacterial infection, medications, or underlying systemic rheumatic disease could be implicated. To our knowledge, small-vessel vasculitis occurring after influenza vaccination has not been previously reported.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Humans
  • Influenza Vaccines / adverse effects*
  • Male
  • Vaccination / adverse effects*
  • Vasculitis / etiology*


  • Influenza Vaccines