beta-Endorphin. Intravenous infusion causes behavioral change in psychiatric inpatients

Arch Gen Psychiatry. 1980 Jun;37(6):642-7. doi: 10.1001/archpsyc.1980.01780190040005.


Ten depressed and eight schizophrenic patients received synthetic human beta-endorphin infusions in a double-blind, placebo-controlled, crossover design. Physicians' and nurses' ratings and patients' self-ratings were used to measure behavioral change. Depressed patients improved significantly two to four hours after beta-endorphin treatment when compared with placebo treatment. There was no significant change in the schizophrenic patients as a group, although six of eight worsened after beta-endorphin treatment. No significant behavioral effects were observed during the infusions themselves or on postinfusion days.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Depression / drug therapy*
  • Depression / psychology
  • Double-Blind Method
  • Endorphins / therapeutic use*
  • Female
  • Humans
  • Infusions, Parenteral
  • Male
  • Middle Aged
  • Schizophrenia / drug therapy*
  • Schizophrenic Psychology


  • Endorphins