Common bile duct pressure during enflurane anesthesia. Effects of morphine and subsequent naloxone

Arch Surg. 1980 Jul;115(7):820-2. doi: 10.1001/archsurg.1980.01380070014003.


In ten otherwise healthy patients undergoing cholecystectomy and cholangiography, morphine sulfate, in a dose of 2.5 mg/70 kg body weight, significantly elevated common bile duct pressure, as measured by water manometry, two and five minutes after intravenous injection. There was no added effect from an additional 7.5 mg/70 kg, measured two and five minutes after injection. Naloxone hydrochloride, in a dose of 1.0 mg/70 kg body weight, quickly reversed the increase in pressure caused by the morphine. Radiographic contrast material passed into the duodenum in every patient after administration of naloxone.

MeSH terms

  • Adult
  • Anesthetics
  • Biliary Tract Diseases / diagnostic imaging
  • Biliary Tract Diseases / surgery
  • Cholangiography
  • Cholecystectomy*
  • Common Bile Duct / drug effects*
  • Enflurane
  • Female
  • Humans
  • Male
  • Morphine / pharmacology*
  • Naloxone / pharmacology*
  • Pressure


  • Anesthetics
  • Naloxone
  • Morphine
  • Enflurane