Paroxysmal nocturnal haemoglobinuria in pregnancy: case report

Br J Obstet Gynaecol. 1980 Mar;87(3):246-8. doi: 10.1111/j.1471-0528.1980.tb04528.x.


Pregnancy in a woman with paroxysmal nocturnal haemoglobinuria was complicated by hepatic venous thrombosis, portal hypertension and haematemesis due to gross oesophageal varices. Labour was induced and a live female infant was born. Dural sinus thrombosis and intracerebral haemorrhage resulted in death on the 46th day post partum. A review of the literature shows that venous thrombosis is common in paroxysmal nocturnal haemoglobinuria.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Budd-Chiari Syndrome / drug therapy
  • Budd-Chiari Syndrome / etiology*
  • Female
  • Hemoglobinuria, Paroxysmal / complications*
  • Heparin / therapeutic use
  • Humans
  • Intracranial Embolism and Thrombosis / etiology*
  • Pregnancy
  • Pregnancy Complications, Hematologic* / drug therapy
  • Puerperal Disorders / etiology


  • Heparin