Effect of treatment with phenformin, diphenylhydantoin or L-dopa on life span and tumour incidence in C3H/Sn mice

Gerontology. 1980;26(5):241-6. doi: 10.1159/000212423.

Abstract

The chronic treatment of female C3H/Sn mice with phenformin (2 mg/day) and diphenylhydantoin (2 mg/day) prolonged mean life span by 23 and 25%, respectively, and decreased spontaneous tumour incidence by 4.0 and 2.3 times, respectively. The chronic treatment of mice with L-dopa (2 mg/day) did not change these parameters and decreased the multiplicity of mammary tumours. The mechanisms of the drug action on mouse life span and tumour incidence are discussed.

MeSH terms

  • Adenocarcinoma / prevention & control
  • Aging / drug effects*
  • Animals
  • Female
  • Leukemia, Experimental / prevention & control
  • Levodopa / pharmacology*
  • Mammary Neoplasms, Experimental / prevention & control
  • Mice
  • Mice, Inbred C3H
  • Neoplasms, Experimental / prevention & control*
  • Phenformin / pharmacology*
  • Phenytoin / pharmacology*

Substances

  • Levodopa
  • Phenytoin
  • Phenformin