Nutrition in the Multiple Risk Factor Intervention Trial (MRFIT)

J Am Diet Assoc. 1980 Apr;76(4):347-51.


The Multiple Risk Factor Intervention Trial (MRFIT) is a clinical trial to determine whether primary prevention of coronary heart disease (CHD) is achievable. The main objective is to learn whether a special intervention program for men at increased risk of death from CHD can result in a significant reduction in mortality from this disease. For this investigation, 12,866 men, ages thirty-five to fifty-seven years, have been enrolled, after having been identified at increased risk because of a combination of risk factors: Elevated serum cholesterol, elevated diastolic blood pressure, and cigarette smoking. MRFIT provides an excellent opportunity for nutritionists to work closely with physicians, behavioral scientists, nurses, and other scientists in a program to change food habits, reduce blood pressure, and achieve cessation of smoking.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cholesterol / blood
  • Coronary Disease / prevention & control*
  • Humans
  • Hypertension / diagnosis
  • Male
  • Middle Aged
  • Multiphasic Screening
  • Probability*
  • Risk*
  • Smoking Prevention


  • Cholesterol