C-Glucuronidation of the acetylenic moiety of ethchlorvynol in the rabbit

Science. 1980 Aug 8;209(4457):703-4. doi: 10.1126/science.7394528.

Abstract

An acetylenic C-glucuronide of the sedative-hypnotic drug ethchlorvynol was isolated from rabbit urine as the major metabolite. The C-glucuronide represents a novel metabolic pathway for acetylenes and is a rare example of the formation of a carbon-glucuronide bond in mammalian systems.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetylene
  • Animals
  • Carbon Radioisotopes
  • Ethchlorvynol / analogs & derivatives*
  • Ethchlorvynol / metabolism*
  • Ethchlorvynol / urine
  • Glucuronidase
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Rabbits
  • Spectrophotometry, Infrared

Substances

  • Carbon Radioisotopes
  • ethchlorvynol glucuronide
  • Ethchlorvynol
  • Glucuronidase
  • Acetylene