Multinucleation and polyploidization of aging human cells in culture

Adv Exp Med Biol. 1980;129:31-8. doi: 10.1007/978-1-4684-3734-8_4.


In conclusion, evidence has been presented to show that multinucleation and polyploidization are common, if not ubiquitous, phenomena observable both in proliferating human cell populations in culture, and in cell populations which have already passed through their proliferative phase in culture. A hypothetical model is presented, the essence of which postulates the existence of a regularly controlled cell life, including DNA synthesis, out of cell cycle.

MeSH terms

  • Cell Nucleus / ultrastructure*
  • Cell Survival*
  • Cells, Cultured / ultrastructure*
  • Humans
  • Liver / cytology
  • Lung / cytology
  • Models, Biological
  • Polyploidy*
  • Time Factors