The effect of growth hormone administration on human sleep: a dose-response study

Biol Psychiatry. 1980 Aug;15(4):613-8.


Human growth hormone and saline were administered for one night each to normal volunteers in a cross-over study. A dose of 2 units im given 15 min before bedtime had no effect on sleep EEG parameters. In contrast, 5 units resulted in a 19% decrease in slow-wave sleep (p < 0.01) and a 13% increase in REM sleep (p < 0.05). Neither doe, when given during daytime, affected tests of affect or serial learning.

MeSH terms

  • Adolescent
  • Adult
  • Dose-Response Relationship, Drug
  • Female
  • Growth Hormone / pharmacology*
  • Humans
  • Male
  • Sleep Stages / drug effects*
  • Sleep, REM / drug effects


  • Growth Hormone