Catechol-O-methyltransferase activity: a determinant of levodopa response

Clin Pharmacol Ther. 1980 Aug;28(2):278-86. doi: 10.1038/clpt.1980.161.


In 14 patients with Parkinson's disease on long-term therapy the erythrocyte catechol-O-methyltransferase activity was found to correlate with the average plasma concentration ratio of 3-O-methyldopa to levodopa and with the fasting plasma concentration ratio of 3-O methyldopa to levodopa. Patients with the higher erythrocyte catechol-O-methyltransferase activities were those with less favorable clinical responses to levodopa. Since erythrocyte catechol-O-methyltransferase activity may reflect the activity of that enzyme in the major metabolizing tissues, catechol-O-methyltransferase activity would seem to be a significant determinant of response to levodopa.

MeSH terms

  • Aged
  • Catechol O-Methyltransferase / analysis
  • Catechol O-Methyltransferase / blood*
  • Catechol O-Methyltransferase Inhibitors
  • Erythrocytes / enzymology
  • Female
  • Humans
  • Kidney / enzymology
  • Levodopa / blood
  • Levodopa / metabolism
  • Levodopa / therapeutic use*
  • Liver / enzymology
  • Male
  • Methyldopa / blood
  • Middle Aged
  • Parkinson Disease / drug therapy*
  • Parkinson Disease / enzymology
  • Time Factors


  • Catechol O-Methyltransferase Inhibitors
  • Levodopa
  • Methyldopa
  • Catechol O-Methyltransferase