Podophyllum: suspected teratogenicity from topical application

Clin Toxicol. 1980 May;16(3):283-6. doi: 10.3109/15563658008989950.


A case demonstrating suspected teratogenic effects of topical podophylium is presented. Podophyllum resin was applied five times for a duration of 4 hr from the 23rd to the 29th week of pregnancy. At birth a simian crease on the left hand and a preauricular skin tag were noted. It is suggested that podophyllum be avoided during pregnancy. Alternative treatment for warts of the vaginal, perineal, or anal area are presented.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Drug-Induced / etiology
  • Administration, Topical
  • Adult
  • Chloroquine / toxicity
  • Condylomata Acuminata / drug therapy
  • Female
  • Humans
  • Podophyllin / toxicity*
  • Pregnancy
  • Pregnancy Complications, Infectious / drug therapy
  • Teratogens*


  • Teratogens
  • Chloroquine
  • Podophyllin