Clinical pharmacokinetics of alcuronium chloride in man

Eur J Clin Pharmacol. 1980 Jun;17(6):449-57. doi: 10.1007/BF00570163.


The pharmacokinetic behaviour of alcuronium is described for nineteen patients undergoing anaesthesia for elective surgery. Eleven patients received a single bolus intravenous dose of 0.25 mg/kg, while 8 patients required additional doses of 0.125 mg/kg. A two-compartment open model was found to describe adequately both the single dose and multiple dose data for the majority of patients. No significant differences were found in the model-independent pharmacokinetic parameters between the single and multiple dose studies. Mean values for the pooled data for the half-life (t 1/2 beta), apparent volume of distribution (Vd beta), volume of distribution at steady-state (Vdss), volume of the central compartment (Vc) and plasma clearance (Clp) were 198.75 min, 24.261, 20.891, 8.181 and 90.22 ml/min respectively. Evoked muscle twitch response was monitored in 17 of the patients to assess the degree of relaxant blockade. The bolus dose of alcuronium produced complete block in 9 patients and between 95 and 99% block in the remainder. The time of onset to maximum block ranged from 3 to 30 min with the concurrently measured plasma levels of alcuronium being 0.79 to 2.25 microgram/ml. The time taken following bolus administration to 5% recovery (95% paralysis) was a mean of 42 min and the corresponding mean alcuronium plasma concentration was 0.78 microgram/ml.

MeSH terms

  • Adult
  • Aged
  • Alcuronium / administration & dosage
  • Alcuronium / blood
  • Alcuronium / metabolism*
  • Drug Administration Schedule
  • Female
  • Half-Life
  • Humans
  • Kinetics
  • Male
  • Metabolic Clearance Rate
  • Middle Aged
  • Models, Theoretical
  • Paralysis / chemically induced
  • Time Factors
  • Toxiferine / analogs & derivatives*


  • Toxiferine
  • Alcuronium