Medullary cardiovascular effects of tetrodotoxin in anaesthetized cats

Eur J Pharmacol. 1980 Jul 25;65(2-3):293-6. doi: 10.1016/0014-2999(80)90404-5.

Abstract

Tetrodotoxin injected in the cat nucleus tracus solitarii produced hypertension without bradycardia, whereas in the nucleus reticularis lateralis it led to hypotension and bradycardia. Tetrodotoxin acts by blocking neuronal activity; it is a useful tool for studying the central organization of cardiovascular regulation. The present data confirm that the nucleus reticularis lateralis is a vasopressive centre.

MeSH terms

  • Anesthesia
  • Animals
  • Blood Pressure / drug effects
  • Cats
  • Cerebellar Nuclei / drug effects
  • Female
  • Heart Rate / drug effects
  • Hemodynamics / drug effects*
  • Male
  • Medulla Oblongata / drug effects*
  • Microinjections
  • Tetrodotoxin / pharmacology*

Substances

  • Tetrodotoxin