Medullary cardiovascular effects of tetrodotoxin in anaesthetized cats

Eur J Pharmacol. 1980 Jul 25;65(2-3):293-6. doi: 10.1016/0014-2999(80)90404-5.


Tetrodotoxin injected in the cat nucleus tracus solitarii produced hypertension without bradycardia, whereas in the nucleus reticularis lateralis it led to hypotension and bradycardia. Tetrodotoxin acts by blocking neuronal activity; it is a useful tool for studying the central organization of cardiovascular regulation. The present data confirm that the nucleus reticularis lateralis is a vasopressive centre.

MeSH terms

  • Anesthesia
  • Animals
  • Blood Pressure / drug effects
  • Cats
  • Cerebellar Nuclei / drug effects
  • Female
  • Heart Rate / drug effects
  • Hemodynamics / drug effects*
  • Male
  • Medulla Oblongata / drug effects*
  • Microinjections
  • Tetrodotoxin / pharmacology*


  • Tetrodotoxin