[Local therapy of androgenetic alopecia with 17 alpha-estradiol. A controlled, randomized double-blind study (author's transl)]

Dermatologica. 1980;161(2):124-32.
[Article in German]


In a controlled, randomized double-blind study, 51 patients with androgenetic alopecia and increased hair loss (telogen rate greater than 20%) were treated by local application of hair lotions with and without 17 alpha-estradiol (0.025%) for a period of at least 6 months. Before and after therapy trichograms were taken and evaluated under standardized conditions. In 63% of the treated patients a reduction of the amount of telogen hairs appeared, whereas in the control group the same reduction was found in only 37% of the cases. Similarly, in the treated group only 11% of the patients worsened, in contrast to 50% of the control group who showed an increased telogen rate (greater than 10%). The amount of growing anagen hairs and of seborrhea did not change significantly in both groups. Side effects were not seen. These findings indicate that hair lotions containing 17 alpha-estradiol may have a therapeutic value in reducing androgenetic hair loss, if applied topically for a long period of time, similar to 17 beta-estradiol. However, no regrowth of new hair was found.

Publication types

  • Clinical Trial
  • Comparative Study
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Adolescent
  • Adult
  • Alopecia / drug therapy*
  • Double-Blind Method
  • Estradiol / administration & dosage
  • Estradiol / therapeutic use*
  • Female
  • Humans
  • Male
  • Middle Aged


  • Estradiol