Neurotensin and its amide analogue [Gln4]-neurotensin: effects on brain monoamine turnover

Naunyn Schmiedebergs Arch Pharmacol. 1978 Dec;305(3):213-8. doi: 10.1007/BF00498813.


Intracerebroventricularly administered neurotensin and [Gln4]-neurotensin (50-200 microgram) increased the formation of Dopa in different brain regions of rats after inhibition of the aromatic L-amino acid decarboxylase. For both neuropeptides these increases were dose dependent (20-150%). In the corpus striatum [Gln4]-neurotensin was twice as active as neurotensin and it tended to be more active also in other brain regions. The brain tyrosine concentrations were also increased. [Gln4]-neurotensin (100-200 microgram) following inhibition of the aromatic L-amino acid decarboxylase, increased the accumulation of 5-hydroxytryptophan in all brain regions by 30-60%. In contrast, neurotensin was completely inactive. In both cases the brain tryptophan concentrations were increased. Both neurotensin and [Gln4]-neurotensin also accelerated the disappearance of dopamine, noradrenaline and 5-hydroxytryptamine after inhibition of monoamine synthesis. These results show an increased brain monoamine turnover induced by both neuropeptides.

MeSH terms

  • Animals
  • Behavior, Animal / drug effects
  • Biogenic Amines / metabolism*
  • Brain / drug effects
  • Brain / metabolism*
  • Hydroxylation
  • Injections, Intraventricular
  • Male
  • Neurotensin / administration & dosage
  • Neurotensin / analogs & derivatives*
  • Neurotensin / pharmacology*
  • Rats
  • Tryptophan / metabolism
  • Tyrosine / metabolism


  • Biogenic Amines
  • Neurotensin
  • Tyrosine
  • Tryptophan