The breakdown of collagen by chondrocytes

J Pathol. 1980 Mar;130(3):159-67. doi: 10.1002/path.1711300304.


The chondrocytes of pure articular cartilage from young pigs display collagenolytic activity when the cartilage is cultivated by an organ culture method in medium containing 5--10 IU retinol/ml. Breakdown of collagen occurs in all regions of the cartilage; in the thicker explants it is greatest and most frequent in those that contain the deepest zone composed of proliferating and hypertrophic chondrocytes; it is also very drastic in thin explants composed mainly of superficial fibro-cartilage.

MeSH terms

  • Animals
  • Cartilage, Articular / cytology*
  • Cartilage, Articular / drug effects
  • Cartilage, Articular / metabolism
  • Cell Division / drug effects
  • Cell Movement / drug effects
  • Collagen / metabolism*
  • Hydroxyproline / metabolism
  • Metacarpus
  • Organ Culture Techniques
  • Proteoglycans / metabolism
  • Swine
  • Vitamin A / pharmacology


  • Proteoglycans
  • Vitamin A
  • Collagen
  • Hydroxyproline