Preservation of renal function in experimental glomerulonephritis

Kidney Int. 1980 Mar;17(3):293-302. doi: 10.1038/ki.1980.35.

Abstract

To evaluate the protective effect of dietary phosphorus restriction in an immunologic model of experimental renal disease, we randomized 24 Sprague-Dawley rats with established nephrotoxic serum nephritis into two groups. Group A animals (N = 13) were fed a diet with a normal phosphorus content (0.5% phosphorus), and group B animals (N = 11) received an identical diet low in phosphorus (0.04% phosphorus). Over the ensuing 133 days, group A rats developed progressive renal failure and had a mean serum creatinine concentration of 3.0 +/- 0.5 mg/dl at the time of death or completion of the study. In contrast, group B animals maintained near normal renal function and had a final mean serum creatinine concentration of 0.93 + 0.2 mg/dl (P < 0.001). Survival was markedly improved in group B animals (P < 0.001). Histologic damage was diminished greatly in group B animals by both light and electron microscopy; immunofluorescence was positive in all animals. Group A animals had increased kidney calcium concentration (30 +/- 6 mmoles/kg) when compared to group B animals (18 +/- 1 mmoles/kg) and animals with normal kidneys (13 +/- 1 nmoles/kg, P< 0.001). Conclusion. Dietary restriction of phosphorus retards functional deterioration and reduces histologic damage in experimental immunologic renal disease. The mechanism for this protective effect has not been elucidated.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Basement Membrane / immunology
  • Calcium / metabolism
  • Creatinine / blood
  • Diet
  • Glomerulonephritis / diet therapy*
  • Glomerulonephritis / immunology
  • Glomerulonephritis / metabolism
  • Glomerulonephritis / pathology
  • Immune Sera
  • Kidney / metabolism
  • Kidney Cortex / pathology
  • Kidney Glomerulus / immunology
  • Male
  • Phosphorus / administration & dosage*
  • Phosphorus / metabolism
  • Proteinuria
  • Rats

Substances

  • Immune Sera
  • Phosphorus
  • Creatinine
  • Calcium