Abstract
A 27-kilodalton tryptic fragment, derived from the amino terminus of the 200-kilodalton fibronectin subunit, inhibited binding of intact fibronectin to Staphylococcus aureus and could be cross-linked to Staphylococcus aureus by blood coagulation Factor XIIIa. Interactions of fibronectin with Staphylococcus aureus via this fragment may be important for bacterial opsonization and attachment.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Factor XIII / metabolism*
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Fibronectins / metabolism*
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Humans
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Molecular Weight
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Opsonin Proteins
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Peptide Fragments
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Protein Binding
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Staphylococcus aureus / immunology
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Staphylococcus aureus / metabolism*
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Trypsin / metabolism
Substances
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Fibronectins
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Opsonin Proteins
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Peptide Fragments
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Factor XIII
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Trypsin