Binding and factor XIIIa-mediated cross-linking of a 27-kilodalton fragment of fibronectin to Staphylococcus aureus

Science. 1980 Aug 22;209(4459):927-9. doi: 10.1126/science.7403857.

Abstract

A 27-kilodalton tryptic fragment, derived from the amino terminus of the 200-kilodalton fibronectin subunit, inhibited binding of intact fibronectin to Staphylococcus aureus and could be cross-linked to Staphylococcus aureus by blood coagulation Factor XIIIa. Interactions of fibronectin with Staphylococcus aureus via this fragment may be important for bacterial opsonization and attachment.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Factor XIII / metabolism*
  • Fibronectins / metabolism*
  • Humans
  • Molecular Weight
  • Opsonin Proteins
  • Peptide Fragments
  • Protein Binding
  • Staphylococcus aureus / immunology
  • Staphylococcus aureus / metabolism*
  • Trypsin / metabolism

Substances

  • Fibronectins
  • Opsonin Proteins
  • Peptide Fragments
  • Factor XIII
  • Trypsin