Effects of high-protein, low-carbohydrate dieting on plasma lipoproteins and body weight

J Am Diet Assoc. 1980 Sep;77(3):264-70.


Twenty-four obese but otherwise normal men and women were followed for: Two weeks on their usual food intake; eight weeks on a high-protein, low-carbohydrate diet; and then again for two weeks on their usual diet. During this time, several metabolic parameters were measured bimonthly. The high-protein, low-carbohydrate dieting resulted in substantial weight loss, probably due to a combination of salt and water loss, as well as caloric restriction. Plasma triglycerides fell as well. Significant increases occurred in LDL-cholesterol, uric acid, and free fatty acid levels. HDL-cholesterol levels failed to rise despite significant weight loss, indicating that the previously reported relationship between HDL-cholesterol and weight may be dependent, in part, on the composition of the diet.

MeSH terms

  • Adult
  • Body Weight
  • Cholesterol / blood
  • Diet Fads
  • Diet, Reducing / standards*
  • Dietary Carbohydrates / pharmacology*
  • Dietary Proteins / pharmacology*
  • Female
  • Humans
  • Lipoproteins / blood*
  • Lipoproteins, HDL / blood
  • Lipoproteins, LDL / blood
  • Male
  • Middle Aged
  • Sex Factors


  • Dietary Carbohydrates
  • Dietary Proteins
  • Lipoproteins
  • Lipoproteins, HDL
  • Lipoproteins, LDL
  • Cholesterol