Elimination of synapses in the developing nervous system

Science. 1980 Oct 10;210(4466):153-7. doi: 10.1126/science.7414326.

Abstract

Reduction of the number of axons that contact target cells may be a general feature of neural development. This process may underlie the progressively restricted malleability of the maturing nervous system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Axons / physiology
  • Ganglia, Autonomic / ultrastructure
  • Humans
  • Nerve Growth Factors / physiology
  • Nervous System / growth & development*
  • Neural Pathways / growth & development
  • Neuromuscular Junction / ultrastructure
  • Synapses / ultrastructure*

Substances

  • Nerve Growth Factors