Abstract
Hypoxanthine arabinoside pharmacokinetics were measured during an adenine arabinoside continuous intravenous infusion and during hemodialysis in a patient with renal failure. Therapeutic guidelines for adenine arabinoside in renal failure are provided based on an elimination half-life of 4.7 h and a plasma clearance of 87.9 ml/min for the hypoxanthine metabolite.
MeSH terms
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Acute Kidney Injury / metabolism*
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Adolescent
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Arabinonucleosides / blood
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Arabinonucleosides / metabolism*
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Female
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Half-Life
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Herpes Simplex / drug therapy
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Humans
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Hypoxanthines / blood
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Hypoxanthines / metabolism*
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Infusions, Parenteral
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Kinetics
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Metabolic Clearance Rate
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Renal Dialysis
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Vidarabine / metabolism*
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Vidarabine / therapeutic use
Substances
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Arabinonucleosides
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Hypoxanthines
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hypoxanthine arabinoside
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Vidarabine