Under examination was the possibility to reveal clinico-immunological features in patients with soft tissue sarcomas prior to and after surgery. Different immune responses were observed in patients with various forms of tumor progression. In case of a favourable course of the process surgery somewhat stimulates the cell immune response and reduces the titre of humoral antibodies. In patients with the tumor progression despite the employed treatment, a gradual fall of high cell immunity indices with a simultaneous increase of the humoral antibodies titre was noted. Wide metastases spread in the terminal phase is manifested by suppression of the immune response.