Serum immunoglobulin and albumin levels have been determined in 50 male and 50 female Ghanaians from the greater Accra region. The subjects, as far as could be ascertained, were healthy, with no observed parasitaemia or fever within a fortnight of sampling. The results have been analysed and compared with European values obtained from blood-donors of laboratory workers in South East England. As a result of this study normal ranges at the 95% confidence limits are suggested for IgG, IgA, IgM and albumin for urban Ghanaians.