Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 32 (5), 723-30

A Cytogenetic Study of Repeated Spontaneous Abortions

A Cytogenetic Study of Repeated Spontaneous Abortions

T J Hassold. Am J Hum Genet.

Abstract

During a cytogenetic study of spontaneous abortions, successive abortions from 40 couples were karyotyped. The chromosome constitutions of the first and second abortions were found to be highly correlated. In each of 21 instances in which the first abortion was chromosomally normal, the subsequent abortion(s) was normal as well. In nine cases, the two abortions were chromosomally abnormal, and in four of these, both abortions were trisomic. Combined with findings from other studies of consecutive spontaneous abortions, the present data indicate that certain couples are at an increased risk for either repeated chromosomally normal abortions or for repeated trisomic conceptions. The increased risk of trisomy does not seem to be restricted to a particular chromosome, and the magnitude of the risk increase appears to be independent of maternal age.

Similar articles

See all similar articles

Cited by 24 PubMed Central articles

See all "Cited by" articles

References

    1. Ann Hum Genet. 1978 May;41(4):443-54 - PubMed
    1. Hum Hered. 1970;20(1):112-22 - PubMed
    1. Am J Obstet Gynecol. 1978 May 1;131(1):33-8 - PubMed
    1. Br J Obstet Gynaecol. 1975 May;82(5):366-73 - PubMed
    1. Acta Obstet Gynecol Scand Suppl. 1976;52:1-29 - PubMed

Publication types

LinkOut - more resources

Feedback