The effect of theophylline on the lower esophageal sphincter pressure

Ann Allergy. 1980 Oct;45(4):238-41.


The effects of theophylline on lower esophageal sphincter pressure (LESP) were studied on four normal volunteers and six asthmatics with symptoms of gastroesophageal reflux (GER). Manometric evaluations of LESP were obtained before and after an intravenous dose of aminophylline. All subjects had therapeutic theophylline levels at the time of the second measurement of LESP and a significant decrease in LESP occurred in normal and asthmatic volunteers.

MeSH terms

  • Aminophylline / administration & dosage
  • Asthma / drug therapy
  • Esophagogastric Junction / drug effects*
  • Female
  • Humans
  • Male
  • Theophylline / blood
  • Theophylline / pharmacology*
  • Theophylline / therapeutic use


  • Aminophylline
  • Theophylline