Dependence of the cytostatic effect of adriamycin on drug concenration and exposure time in vitro

Br J Cancer. 1980 Jun;41(6):886-91. doi: 10.1038/bjc.1980.165.


The surviving fraction (SF) of Chinese hamster cells and HeLa cells after treatment with a range of Adriamycin concentrations and exposure times was determined. The cytostatic effect was proportional to the product of extracellular drug concentration (c) and exposure time (t) according to the equation: SF=e-ktc. By determining the intracellular drug concentration at various exposures, it could be shown that absorbed dose is not proportional to exposure dose.

MeSH terms

  • Animals
  • Cell Line
  • Cell Survival / drug effects*
  • Cricetinae
  • Cricetulus
  • Dose-Response Relationship, Drug
  • Doxorubicin / pharmacology*
  • HeLa Cells
  • Humans
  • Lung / cytology
  • Time Factors


  • Doxorubicin