Role of attachment factors and attractants in fibroblast chemotaxis

J Lab Clin Med. 1980 Dec;96(6):1071-80.

Abstract

Fibroblasts require both a collagen substratum and fibronectin for adherence and subsequent migration in the Boyden chamber. Both fibronectin and lymphokines are good chemoattractants, whereas the collagens are weaker. Fibroblasts appear to require cytoskeletal organization and methylation reactions for chemotaxis, properties shown previously for macrophages and neutrophils. Fibroblasts, however, migrate more slowly than phagocytic cells and appear to require protein synthesis.

MeSH terms

  • Animals
  • Cattle
  • Cell Adhesion*
  • Chemotactic Factors / analysis
  • Chemotaxis*
  • Collagen / analysis
  • Fibroblasts / cytology*
  • Fibronectins / analysis
  • Humans
  • Methylation

Substances

  • Chemotactic Factors
  • Fibronectins
  • Collagen