Influenza vaccination of elderly persons. Reduction in pneumonia and influenza hospitalizations and deaths

JAMA. 1980 Dec 5;244(22):2547-9.


Effectiveness of influenza vaccination in reducing pneumonia and influenza hospitalizations and deaths among elderly members of a prepaid health plan was analyzed retrospectively. Two epidemics caused by the H3N2 subtype of type A influenza were studied. Vaccine derived from the H2N2 subtype of influenza A virus failed to protect against the Hong Kong (H3N2) virus during the 1968-1969 epidemic. Vaccine derived from the A/Hong Kong/68 (H3N2) virus yielded an estimated 72% (31% to 100%) reduction in hospitalization and 87% (52% to 100%) reduction in mortality during the 1972-1973 epidemic caused by A/England/72 (H3N2). These findings are consistent with those reported in vaccinated young persons, and hence it appears they may be broadly generalized.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age Factors
  • Aged
  • Health Maintenance Organizations
  • Health Services Research*
  • Hospitalization / trends
  • Humans
  • Influenza Vaccines / administration & dosage*
  • Influenza, Human / mortality
  • Influenza, Human / prevention & control*
  • Mortality
  • Oregon
  • Pneumonia / prevention & control*
  • Pneumonia, Viral / prevention & control
  • Probability
  • Retrospective Studies
  • Vaccination / statistics & numerical data


  • Influenza Vaccines