Genetic effects of turmeric and curcumin in mice and rats

Mutat Res. 1980 Oct;79(2):125-32. doi: 10.1016/0165-1218(80)90080-4.

Abstract

Incorporation of either turmeric (0.5%) or curcumin (0.015%) into diets of mice did not show significant effect on the incidence of micronucleated polychromatic erythrocytes, structural and numerical aberrations in bone-marrow chromosomes, pregnancy rate, number of live and dead embryos, total implants and mutagenic index. Also rats fed cooked diets containing turmeric (0.5 and 0.05%) did not show significant differences in the incidence of chromosomal aberrations in their bone marrow.

MeSH terms

  • Animals
  • Body Weight
  • Bone Marrow / drug effects
  • Chromosome Aberrations
  • Chromosomes / drug effects
  • Condiments*
  • Erythrocytes / drug effects
  • Female
  • Fertility / drug effects
  • Fetal Death / chemically induced
  • Food Coloring Agents / pharmacology*
  • Male
  • Mice
  • Mutagenicity Tests
  • Mutagens*
  • Pregnancy
  • Rats

Substances

  • Food Coloring Agents
  • Mutagens