Magnesium stearate given perorally to rats. A short term study

Toxicology. 1980;17(1):51-5. doi: 10.1016/0300-483x(80)90026-8.

Abstract

Magnesium stearate was fed to groups of 20 male and 20 female rats at levels of 0, 5, 10 and 20% in a semisynthetic diet for 3 months. Decreased weight gain was found in males in the 20% group. Urolithiasis was found in 8 males and in 7 females in the same group. Reduced relative liver weight was seen in males in the 10% and in the 20% groups, and an increased amount of iron was found in the livers of the 20% group. Nephrocalcinosis was reduced in females in the 20% group. In this experiment the no-effect-level is estimated to be 5% magnesium stearate in the diet, corresponding to 2500 mg/kg body wt/day.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Body Weight / drug effects
  • Female
  • Kidney / drug effects
  • Liver / drug effects
  • Male
  • Nephrocalcinosis / chemically induced*
  • Organ Size / drug effects
  • Rats
  • Sex Factors
  • Stearates / toxicity*
  • Stearic Acids / toxicity*
  • Urinary Calculi / chemically induced*

Substances

  • Stearates
  • Stearic Acids