Pulmonary alveolar proteinosis in two siblings with decreased immunoglobulin A

Am J Med. 1980 Nov;69(5):786-9. doi: 10.1016/0002-9343(80)90453-2.

Abstract

A brother and sister with classic, biopsy proved pulmonary alveolar proteinosis are described. Both had low serum and low normal secretory immunoglobulin A (IgA) levels. A tendency for familial occurrence is possible and it is recommended that patients with pulmonary alveolar proteinosis, and their families, be evaluated for immunologic deficiencies.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Dysgammaglobulinemia / diagnosis
  • Dysgammaglobulinemia / genetics*
  • Female
  • Humans
  • IgA Deficiency*
  • Immunoglobulin A / analysis
  • Male
  • Pulmonary Alveolar Proteinosis / diagnosis
  • Pulmonary Alveolar Proteinosis / genetics*
  • Pulmonary Alveolar Proteinosis / therapy
  • Pulmonary Alveoli / diagnostic imaging
  • Pulmonary Alveoli / pathology
  • Pulmonary Diffusing Capacity
  • Radiography
  • Therapeutic Irrigation
  • Vital Capacity

Substances

  • Immunoglobulin A