Specific and potent inhibition of spermidine synthase by the transition-state analog, S-adenosyl-3-thio-1,8-diaminooctane

Biochem Biophys Res Commun. 1980 Oct 16;96(3):1371-7. doi: 10.1016/0006-291x(80)90102-3.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenosine / analogs & derivatives*
  • Adenosine / chemical synthesis
  • Adenosine / pharmacology
  • Alkylation
  • Animals
  • Male
  • Prostate / enzymology
  • Rats
  • Spermidine Synthase / antagonists & inhibitors*
  • Structure-Activity Relationship
  • Transferases / antagonists & inhibitors*

Substances

  • S-adenosyl-3-thio-1,8-diaminooctane
  • Transferases
  • Spermidine Synthase
  • Adenosine