Intersubject and dose-related variability after intravenous administration of erythromycin

Br J Clin Pharmacol. 1980 Sep;10(3):273-9. doi: 10.1111/j.1365-2125.1980.tb01755.x.

Abstract

1 It is well-known that considerable variability and unpredictability in serum concentrations results from orally administered erythromycin. 2 Disposition kinetics and their variability were studies in 24 healthy subjects after a single dose of erythromycin lactobionate and four doses were studied to evaluate dose-related variability in five other subjects. 3 Erythromycin kinetics were adequately described by a classical two compartment open model with little intersubject variability. 4 Dose-related variability occurred. Clearance was independent of dose but T1/2 beta and Vdss increased with dose. 5 Data are presented to show that non-invasive sampling of urine and saliva are of limited value in studying erythromycin pharmacokinetics.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Dose-Response Relationship, Drug
  • Erythromycin / administration & dosage
  • Erythromycin / adverse effects
  • Erythromycin / metabolism*
  • Female
  • Humans
  • Injections, Intravenous
  • Male
  • Saliva / analysis
  • Sex Factors

Substances

  • Erythromycin