Cytological evidence for an inactive X chromosome in murine oogonia

Cytogenet Cell Genet. 1980;28(3):203-7. doi: 10.1159/000131531.


Purified fetal mouse germ cell preparations have been analyzed for the presence of a heterochromatic X chromosome at cell division. A single large heterochromatic chromosome is found in oogonia stage germ cells, but such a chromosome is not present in 16-day fetal oocytes. These results support the idea that mitotic stage germ cells are subject to X-chromosome inactivation and that they go through a reactivation step at meiosis.

MeSH terms

  • Animals
  • Female
  • Fetus / ultrastructure*
  • Meiosis
  • Mice
  • Mosaicism*
  • Oogonia / ultrastructure*
  • Ovum / ultrastructure*
  • Sex Chromosomes*
  • X Chromosome*