The elimination of ethanol is known to be accelerated by fructose. Studies of continuous infusions of both ethanol and fructose as the basis for quantitative calculations are not available. In healthy volunteers fructose infusions were given for several hours during and immediately after the end of ethanol infusions. Both increase and elimination of ethanol in blood were effected to the same extent by fructose when compared to control experiments. Average increases in the elimination rates of ethanol were up to 80%; however, each subject displayed individual variations.