Lipofuscin of human retinal pigment epithelium

Am J Ophthalmol. 1980 Dec;90(6):783-91. doi: 10.1016/s0002-9394(14)75193-1.


Analysis of the fluorescent spectra of chloroform-methanol extracts of human retinal pigment epithelium confirmed the presence of lipofuscin pigments in the pigment epithelium of older individuals. Similar fractions in the pigment epithelium of young individuals were present in insufficient quantities for spectral analysis. Electron microscopy of the pigment epithelium of these eyes showed few or no lipofuscin granules in young eyes but large numbers in older eyes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aging*
  • Humans
  • Infant
  • Lipofuscin / analysis*
  • Middle Aged
  • Pigment Epithelium of Eye / analysis*
  • Pigment Epithelium of Eye / pathology
  • Pigments, Biological / analysis*


  • Lipofuscin
  • Pigments, Biological