Abstract
The nephrotoxic potentials of netilmicin and tobramycin given in doses of 180 mg/kg per day for up to 14 days were compared in Fischer rats. At this dosage, tobramycin produced mortality and significant changes in renal structure and function; netilmicin evoked minimal nephrotoxicity.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Anti-Bacterial Agents / toxicity*
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Gentamicins / toxicity*
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Kidney / drug effects*
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Kidney / metabolism
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Kidney / pathology
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Kidney Function Tests
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Male
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Necrosis
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Netilmicin / toxicity*
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Rats
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Tobramycin / toxicity*
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p-Aminohippuric Acid / metabolism
Substances
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Anti-Bacterial Agents
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Gentamicins
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Netilmicin
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Tobramycin
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p-Aminohippuric Acid