Impaired response to pneumococcal vaccine in systemic lupus erythematosus

Arthritis Rheum. 1980 Nov;23(11):1287-93. doi: 10.1002/art.1780231110.


An immunization program with pneumococcal vaccine was carried out in 38 patients with systemic lupus erythematosus (SLE). Mean antibody levels at 1 month and 1 year were significantly lower than in normal controls. This decreased response did not correlate with drug therapy at the time of immunization. Other parameters such as anergy state, renal function, and serum immunoglobulin levels also did not correlate with antibody response. There were no adverse effects noted in the vaccinated group in comparison to matched non-vaccinated SLE patients.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Antibodies, Bacterial / analysis
  • Antibody Formation*
  • Bacterial Vaccines / immunology*
  • Humans
  • Hypersensitivity, Delayed
  • Immunization
  • Immunoglobulin G / analysis
  • Immunoglobulin M / analysis
  • Lupus Erythematosus, Systemic / drug therapy
  • Lupus Erythematosus, Systemic / immunology*
  • Pneumococcal Infections / prevention & control
  • Streptococcus pneumoniae / immunology*


  • Antibodies, Bacterial
  • Bacterial Vaccines
  • Immunoglobulin G
  • Immunoglobulin M