Ultrastructural observations on the pathogenesis of aspirin-induced gastric erosions

Br J Exp Pathol. 1980 Oct;61(5):497-504.

Abstract

It is shown by transmission electron-microscopy that the first structural change in rats, following a dose of aspirin, is to the basement membrane of the endothelial cell of the capillary and post-capillary venule. This leads to the breakdown of small blood vessels before any other cytolytic effect. This is a focal effect and it is proposed that the erosion develops as an ischaemic infarct.

MeSH terms

  • Animals
  • Aspirin / toxicity*
  • Capillaries / drug effects
  • Capillaries / ultrastructure
  • Endothelium / drug effects
  • Endothelium / ultrastructure
  • Female
  • Gastric Mucosa / blood supply
  • Gastric Mucosa / drug effects
  • Gastric Mucosa / ultrastructure*
  • Microscopy, Electron
  • Rats
  • Stomach Diseases / chemically induced*
  • Stomach Diseases / pathology

Substances

  • Aspirin